cdk5 p25 (Sino Biological)
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Sino Biological
cdk5 p25
Cdk5 P25, supplied by Sino Biological, used in various techniques. Bioz Stars score: 93/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cdk5+p25/CDK5%2Fp25%2C+Active/pmc11670061__pnas__2414176121__sapp-49-19-21
Average 93 stars, based on 13 article reviews
Cdk5 P25, supplied by Sino Biological, used in various techniques. Bioz Stars score: 93/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cdk5+p25/CDK5%2Fp25%2C+Active/pmc11670061__pnas__2414176121__sapp-49-19-21
Average 93 stars, based on 13 article reviews
cdk5 p25 - by Bioz Stars,
2026-11
93/100 stars
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Activity Assay:Article Title: Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives as Potential Anti-Cancer Agents. Article Snippet: Results: The cytotoxic screening of the synthesized compounds revealed that pyrazolo[1,5a]pyrimidines (compounds 9c and 11a) had the most potent cytotoxic activity with IC50 = 0.31 μM and 0.34 μM respectively.. Compounds 9c and 11a were further investigated for their kinase inhibitory potencies toward six kinases (CDK5/p25, CK1ð/ε, GSK-3α/β, Dyrk1A, Erk2, and CLK1).. They exhibited effective inhibition of GSK-3α/β (IC50 = 0.196 μM and 0.246 μM, respectively) and Erk2 (IC50 = 0.295 μM and 0.376 μM, respectively). Synthesized:Article Title: Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives as Potential Anti-Cancer Agents. Article Snippet: Results: The cytotoxic screening of the synthesized compounds revealed that pyrazolo[1,5a]pyrimidines (compounds 9c and 11a) had the most potent cytotoxic activity with IC50 = 0.31 μM and 0.34 μM respectively.. Compounds 9c and 11a were further investigated for their kinase inhibitory potencies toward six kinases (CDK5/p25, CK1ð/ε, GSK-3α/β, Dyrk1A, Erk2, and CLK1).. They exhibited effective inhibition of GSK-3α/β (IC50 = 0.196 μM and 0.246 μM, respectively) and Erk2 (IC50 = 0.295 μM and 0.376 μM, respectively). Enzyme-linked Immunosorbent Assay:Article Title: Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives as Potential Anti-Cancer Agents. Article Snippet: Results: The cytotoxic screening of the synthesized compounds revealed that pyrazolo[1,5a]pyrimidines (compounds 9c and 11a) had the most potent cytotoxic activity with IC50 = 0.31 μM and 0.34 μM respectively.. Compounds 9c and 11a were further investigated for their kinase inhibitory potencies toward six kinases (CDK5/p25, CK1ð/ε, GSK-3α/β, Dyrk1A, Erk2, and CLK1).. They exhibited effective inhibition of GSK-3α/β (IC50 = 0.196 μM and 0.246 μM, respectively) and Erk2 (IC50 = 0.295 μM and 0.376 μM, respectively). other:Article Title: 2-Aminophenones, a common precursor to N-aryl isatins and acridines endowed with bioactivities Article Snippet: The transmitted signal was measured using the Envision (PerkinElmer, Waltham, MA) microplate luminometer and expressed in Relative Light Unit (RLU). In Vitro:Article Title: Cyclin-dependent Kinase 5 Phosphorylation of Familial Prion Protein Mutants Exacerbates Conversion into Amyloid Structure Article Snippet: Western Blot Analyses—Proteins were separated by 15% SDS-PAGE, transferred to PVDF membranes, and immunostained with anti-PrPS43 R48 antiserum (1:10,000) (15), antiPrP109 –112 3F4 antibody (1:3000) (22), anti-PrP36 –56 R155 antiserum (1:5000) (20), and anti-PrP79 –92 SAF32 antibody (1:3000) (Bertin Pharma, Montigny, France). .. In Vitro Kinase Assay and Densitometry—In vitro kinase (IVK) reactions were set up with 16.8 M PrP, 1.84 pmol of Kinase Assay:Article Title: Cyclin-dependent Kinase 5 Phosphorylation of Familial Prion Protein Mutants Exacerbates Conversion into Amyloid Structure Article Snippet: Western Blot Analyses—Proteins were separated by 15% SDS-PAGE, transferred to PVDF membranes, and immunostained with anti-PrPS43 R48 antiserum (1:10,000) (15), antiPrP109 –112 3F4 antibody (1:3000) (22), anti-PrP36 –56 R155 antiserum (1:5000) (20), and anti-PrP79 –92 SAF32 antibody (1:3000) (Bertin Pharma, Montigny, France). .. In Vitro Kinase Assay and Densitometry—In vitro kinase (IVK) reactions were set up with 16.8 M PrP, 1.84 pmol of Phospho-proteomics:Article Title: GSK3β phosphorylation catalyzes the aggregation of tau into Alzheimer's disease-like filaments Article Snippet: Phosphorylation of 200 μM tau was performed in the presence of 2.5 μM of MARK2cat WT kinase (purified in-house), 5 mM ATP, 1 mM Benzamidine, 2 mM EGTA, 1 mM PMSF in 25 mM Tris, 100 mM NaCl, 5 mM MgCl2, 1 mM DTT, pH 8.0 buffer for a duration of 12 hours at 30 °C with 300 rpm shaking in an Eppendorf thermomixer. .. Phosphorylation of 200 μM tau was performed with either 0.02 mg/ml of GSK3 (ab60863, Abcam) or 0.02 mg/ml of |
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